Toxic decks are different from most archetypes inMarvel Snap, mostly because not many people play them. This isn’t because the decks are bad in any way, but they require an understanding of what your opponent is playing and when.
Another thing keeping these types of decks from the spotlight is the lack of support, so whenever a new card comes around for the archetype, it shows how much it can bloom. In this case, Man-Thing comes with a great way to constantly remove power from your opponent’s side.

10The Hood
When playing The Hood, you have to consider not only what to do with the main body but also where to place The Demon. While The Demon more than makes up for The Hood’s negative power, you can also use that negativity to your advantage.
you may always destroy The Hood, or send it over to their side. There are plenty of tricks to do, but destroy-focused decks will be your undoing here. For The Demon, consider playing him as late as possible. Not only you’d be protecting the card, but also it can be a great surprise later on.

9Carnage
In your efforts to fill your opponent with garbage, some might spill to your side. Maybe you have more rocks than you know what to do with, or maybe you didn’t draw Viper and can’t send The Hood over. For those cases, unclogging your side with destroy cards is your best bet.
Among the possible cards you could add, Carnage is the clear winner. Not only is he the lowest cost kill card, but he gains power the more he slays. You can fake out your opponent, making them think you’ll send something over, only to have Carnage gobble it up.

8Hazmat
Hazmat can be tricky to use, since you need to make sure she won’t hit you more than your opponent. While you can easily solve this with Luke Cage, he’s a popular card so you should think about countermeasures, something like Rogue would be ideal.
Yet, Hazmat is worth the trouble, because when she works she shines. As opposed to other, more popular cards, it’s hard to expect the Hazmat play. Combine her with the ability of Man-Thing, and both zoo and bounce decks will have a hard time beating your toxic power.

7Luke Cage
To avoid being hit by your own toxicity, you’ll likely need Luke Cage. He alone can prevent all your work to affect you, but so can your opponents do the same. So, while he’s a worthwhile addition to your deck, you should be more concerned about countering him when he appears on the other side.
While Enchantress might seem like a good idea, in a deck with Man-Thing it becomes less so. The ideal candidate is Rogue, since she not only removes the power from their side but also gives it to you. This means that Rogue has the potential of replacing Luke in matches that you don’t draw him.

6Viper
The queen of the toxic archetype, Viper can deal fatal blows to your opponent’s plans, filling locations they weren’t expecting and possibly sending loads of negative power. Since she has so much potential, she can also be easily predicted, so keep that in mind.
There are matches where you’ll want to use her early, particularly if you get the chance. Other times, you’ll want to save her, especially with Sentry in hand. This is highly meta dependent, since, if your opponent aims to fill all locations, waiting too long might be highly detrimental to your game plan.

5Green Goblin
Green Goblin is the most straightforward card in the deck, since he needs little to no set up. While you might consider adding Hobgoblin as well, he’s too expensive for everything else you’re trying to do in the deck.
This doesn’t mean that Green Goblin comes without risk, since against quickly flooding decks, turn three might be too late, particularly with cards like Jeff or Kitty Pryde. While playing the Goblin where your opponent has three cards is tempting, be careful to not end up with the negative power yourself.

4Debrii
For plans involving negative power on your opponent’s side, Debrii is great. She adds a bunch of rocks that your opponent rarely has any use of, and the more units on their side the better your Hazmat. Be careful to not fill your side too quickly as well.
All the rocks Debrii adds is why you put Carnage in the deck, since he’ll constantly have something to eat when you play him. Again, your worst enemy is destroy-heavy decks, so be sure to not give them fuel and consider retreating when encountering them.

3Sentry
Sentry, much like The Hood, has two bodies you have to consider when playing him. While both are impactful, you have very little control of where to place them. You’ll have to maneuver around Sentry instead of with him, but the reward is well worth it.
On the one hand, you have a ten-power body that can swing the game in your favor. On the other, there’s the Void, a negative-ten-power creature that shows up on the left location. Don’t feel forced to always wait for Viper; filling out the left is also a valid option to ensure a victory.

2Spider-Woman
Not all toxic decks add Spider-Woman, even though her power output is excellent. For most, she’s too heavy, much like the problem you have when adding Hobgoblin. The difference is the consistency, and how well she uses everything else you’re trying to do.
While running Hazmat is all well and good, you won’t draw her all the time. In some cases, that means your rocks are left without much use, beyondblocking a Galactus play. With Spider-Woman, you have to understand that more often than not she’s more than an eight-power play.

1Alioth
While destroy cards are not a staple of toxic decks, Alioth is too good to pass up. He doesn’t interfere with any of your strategies, all the opposite. At the end of the match, your opponent is left with a single move to win the game; deny it, and you’ll take home the victory.
You do need to play around priority with him — if you let them go first, they might put down Doctor Doom and ruin your play. You also have to contend with him being the obvious play, so while your opponent will always consider you having Alioth in hand, you might want to play around them knowing that.